HCID 20542073, compound → HCID 20542108, compound

HRID 2286179Notes

Reaction equation

HRID 2286179 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16]([C:19]#[N:20])[CH:17]=[CH:18][C:13]=2[N:12]([CH3:21])[C:11](=[O:22])[CH2:10][N:9]=1>CO.N.[Ni]>[NH2:20][CH2:19][C:16]1[CH:17]=[CH:18][C:13]2[N:12]([CH3:21])[C:11](=[O:22])[CH2:10][N:9]=[C:8]([C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[F:1])[C:14]=2[CH:15]=1

Participants

5

Reactant 1

HCID 20542073HCID 20542073, compound

Product 1

HCID 20542108HCID 20542108, compound

Reagents, catalysts & solvents 3

HCID 935NickelCatalystHCID 222AmmoniaSolventHCID 887MethanolSolvent

Procedure

36.5 g (0.08 mol) of 5-(o-fluorophenyl)-2,3-dihydro-1-methyl-2-oxo-1H-1,4-benzodiazepine-7-carbonitrile, dissolved in 2700 ml of methanol and 270 ml of ammonia, are hydrogenated in an autoclave with 36.5 g of Raney-nickel at 50° and 3.5 atmospheres. The catalyst is filtered off and the solvent is removed in vacuo. There is obtained 7-(aminomethyl)-5-(o-fluorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one as a foam.

Workup

  1. filtrationThe catalyst is filtered off
  2. customthe solvent is removed in vacuo

Sources & evidence

ORD record
ord-f1334ec7051c4cc1b47b8f6231c7754b
Source dataset
uspto-grants-1982_04
Patent number
US04327026

Reaction notes

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