HCID 20542073, compound → HCID 20542108, compound

Participants

Reaction Steps

36.5 g (0.08 mol) of 5-(o-fluorophenyl)-2,3-dihydro-1-methyl-2-oxo-1H-1,4-benzodiazepine-7-carbonitrile, dissolved in 2700 ml of methanol and 270 ml of ammonia, are hydrogenated in an autoclave with 36.5 g of Raney-nickel at 50° and 3.5 atmospheres. The catalyst is filtered off and the solvent is removed in vacuo. There is obtained 7-(aminomethyl)-5-(o-fluorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one as a foam.

Provenance & Evidence