Formaldehyde → HCID 15575063, compound

HRID 2286196Notes

Reaction equation

HRID 2286196 reaction equation
[O:1]=[C:2]1[N:7]([CH2:8][C:9]#[CH:10])[C:6](=[O:11])[CH:5]=[N:4][NH:3]1.[CH2:12]=[O:13].[OH-].[K+].O>C(O)(=O)C>[OH:13][CH2:12][N:3]1[C:2](=[O:1])[N:7]([CH2:8][C:9]#[CH:10])[C:6](=[O:11])[CH:5]=[N:4]1

Participants

6

Reactant 4

HCID 712FormaldehydeHCID 962WaterHCID 14797Potassium HydroxideHCID 12836710HCID 12836710, compound

Product 1

HCID 15575063HCID 15575063, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
50 °C

Procedure

A mixture of 2.08 g 3,5-dioxo-4-propargyl-2,3,4,5-tetrahydro-1,2,4-triazine, 4.1 ml 35% aqueous formalin, 0.78 g potassium hydroxide and 7 ml water was stirred at 50° C. for 4 hours. After cooling to room temperature, the reaction solution was neutralized to a pH of 7 with acetic acid and extracted with three 30-ml portions of chloroform. The chloroform layers were combined, washed with 10 ml sodium chloride-saturated water and dried over magnesium sulfate. Chloroform was concentrated under reduced pressure to obtain a pale yellow semi-solid.

Workup

  1. temperatureAfter cooling to room temperature
  2. extractionextracted with three 30-ml portions of chloroform
  3. washwashed with 10 ml sodium chloride-saturated water
  4. dry with materialdried over magnesium sulfate
  5. concentrationChloroform was concentrated under reduced pressure
  6. customto obtain a pale yellow semi-solid

Sources & evidence

ORD record
ord-b1a669cad8db4afd87ac47eeb038d1f6
Source dataset
uspto-grants-1982_04
Patent number
US04327094

Reaction notes

Loading…