Sodium Hydroxide → HCID 12795492, compound

HRID 2286206Notes

Reaction equation

HRID 2286206 reaction equation
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]([F:15])=[C:10]([CH3:14])[C:11]=2[F:13])[C:6](=[O:16])[C:5]([C:17]([O:19]CC)=[O:18])=[CH:4]1)[CH3:2].[OH-].[Na+]>C(O)C>[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]([F:15])=[C:10]([CH3:14])[C:11]=2[F:13])[C:6](=[O:16])[C:5]([C:17]([OH:19])=[O:18])=[CH:4]1)[CH3:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 12795490HCID 12795490, compound

Product 1

HCID 12795492HCID 12795492, compoundYield 90.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2.95 g of ethyl 1-ethyl-6,8-difluoro-7-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate are suspended in 50 ml of ethanol, and 50 ml of an aqueous 2% sodium hydroxide solution are added thereto. The suspension is stirred at room temperature for 2 hours. Then, the reaction mixture is evaporated to remove solvent, and the residue is adjusted to about pH 1 with 10% hydrochloric acid. The crystalline precipitates are collected by filtration, washed with water and then dried. 2.41 g of 1-ethyl-6,8-difluoro-7-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid are thereby obtained as crystalline powder. Yield: 90%

Workup

  1. customThen, the reaction mixture is evaporated
  2. customto remove solvent
  3. customThe crystalline precipitates
  4. filtrationare collected by filtration
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-9ad21b0fff1842bb88d91b89a25a7c15
Source dataset
uspto-grants-1982_04
Patent number
US04327101

Reaction notes

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