Sodium Hydroxide → HCID 12795492, compound

Participants

Reaction Steps

2.95 g of ethyl 1-ethyl-6,8-difluoro-7-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate are suspended in 50 ml of ethanol, and 50 ml of an aqueous 2% sodium hydroxide solution are added thereto. The suspension is stirred at room temperature for 2 hours. Then, the reaction mixture is evaporated to remove solvent, and the residue is adjusted to about pH 1 with 10% hydrochloric acid. The crystalline precipitates are collected by filtration, washed with water and then dried. 2.41 g of 1-ethyl-6,8-difluoro-7-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid are thereby obtained as crystalline powder. Yield: 90%

Provenance & Evidence