Phenyl chloroformate → HCID 20542235, compound

HRID 2286217Notes

Reaction equation

HRID 2286217 reaction equation
Cl[C:2]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:3].[Cl:11][C:12]1[CH:13]=[CH:14][C:15]([N:18]2[CH:22]([OH:23])[C:21]3[S:24][CH2:25][CH:26]([O:29][CH3:30])[CH2:27][S:28][C:20]=3[C:19]2=[O:31])=[N:16][CH:17]=1>N1C=CC=CC=1>[Cl:11][C:12]1[CH:13]=[CH:14][C:15]([N:18]2[CH:19]([O:31][C:2]([O:4][C:5]3[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=3)=[O:3])[C:20]3[S:28][CH2:27][CH:26]([O:29][CH3:30])[CH2:25][S:24][C:21]=3[C:22]2=[O:23])=[N:16][CH:17]=1

Participants

4

Reactant 2

HCID 15891Phenyl chloroformateHCID 13017825HCID 13017825, compound

Product 1

HCID 20542235HCID 20542235, compoundYield 60.9%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

By reacting phenyl chloroformate (16.7 g) with 7-(5-chloropyrid-2-yl)-6-hydroxy-3-methoxy-8-oxo-3,4,7,8-tetrahydro-2H,6H-1,4-dithiepino[2,3-c]-pyrrole (prepared as described in Example 1; 12.3 g) in anhydrous pyridine (100 cc) at between -10° C. and +20° C., 7-(5-chloropyrid-2-yl)-3-methoxy-8-oxo-6-phenoxycarbonyloxy-3,4,7,8-tetrahydro-2H,6H-1,4-dithiepino[2,3-c]pyrrole (m.p. 167° C.; 10.1 g) is obtained.

Workup

  1. customat between -10° C. and +20° C.

Sources & evidence

ORD record
ord-198c9e1b30d04b06b2c56478f019f5cd
Source dataset
uspto-grants-1982_04
Patent number
US04327095

Reaction notes

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