Acetic Acid → HCID 20542421, compound

HRID 2286263Notes

Reaction equation

HRID 2286263 reaction equation
[CH3:1][O:2]/[N:3]=[C:4](/[C:7]1[CH:12]=[N:11][CH:10]=[CH:9][N:8]=1)\[C:5]#[N:6].C(O)(=[O:15])C.OO>O>[CH3:1][O:2]/[N:3]=[C:4](/[C:7]1[CH:12]=[N+:11]([O-:15])[CH:10]=[CH:9][N:8]=1)\[C:5]#[N:6]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 784Hydrogen PeroxideHCID 957691779378-26-0

Product 1

HCID 20542421HCID 20542421, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
70 °C

Procedure

A mixture of Z-α-methoxyiminopyrazineacetonitrile (4 g), acetic acid (15 ml) and 30% hydrogen peroxide in water (15 ml) was heated at a temperature of 70° C. over one night. The reaction mixture was concentrated and treated with water and chloroform. The chloroform layer was separated and dried over magnesium sulphate. Evaporation of the solvent and successive crystallization of the residue from alcohol afforded Z-α-methoxyimino-2-pyrazineacetonitrile-4-oxide, m.p. 144°-145° C.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. additiontreated with water and chloroform
  3. customThe chloroform layer was separated
  4. dry with materialdried over magnesium sulphate
  5. customEvaporation of the solvent and successive crystallization of the residue from alcohol

Sources & evidence

ORD record
ord-8935e49312484987aa8f2135c8c3ed0f
Source dataset
uspto-grants-1982_04
Patent number
US04327213

Reaction notes

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