Acetone → HCID 13060841, compound

HRID 2286273Notes

Reaction equation

HRID 2286273 reaction equation
[SH:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[Br:13][CH:14]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:15]([OH:17])=O.[CH3:24][C:25](C)=[O:26].C(OC(=O)C)(=O)C>C(O)(=O)C>[Br-:13].[C:25]([O:17][C:15]1[N+:6]2[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:4][S:3][C:2]=2[S:1][C:14]=1[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)(=[O:26])[CH3:24]

Participants

6

Reactant 4

HCID 180AcetoneHCID 7918Acetic AnhydrideHCID 97919Bromo(phenyl)acetic acidHCID 178470768HCID 178470768, compound

Product 1

HCID 13060841HCID 13060841, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 10.0 g (0.05 m.) 2-mercapto-thiazole-4-acetic acid, ethyl ester (prepared according to U.S. Pat. No. 2,766,238) and 10.75 g. (0.05 m.) α-bromophenylacetic acid in 200 ml. of acetone and 20 ml. each of glacial acetic acid and acetic anhydride is heated in an open flask for two hours. The solvents are removed and the residual solid triturated with acetone. 12 g. of title product is obtained, m.p. 160°-170° C. (dec.).

Workup

  1. customprepared
  2. customThe solvents are removed
  3. customthe residual solid triturated with acetone

Sources & evidence

ORD record
ord-642fa23ddd56403e9565b27ca276f2c3
Source dataset
uspto-grants-1982_04
Patent number
US04327221

Reaction notes

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