反应详情

2-Methyl-5-acetamido aniline (49.2 g, 0.3 m), triethyl amine (32.7 g, 0.3 m) and p-dioxane (350 ml) are stirred together at room temperature. 2-Chloroethane sulfonylfluoride (43.0 g, 0.3 m) is added dropwise allowing temperature to rise to 45° C. The reaction mixture is then heated at reflux for 3 hrs. When thin-layer chromatography shows reaction to be complete, the reaction is allowed to cool and then drowned into water (2000 ml). The product is collected by filtration, washed with water and melts at 154°-155° C.

1. customto rise to 45° C
2. temperatureThe reaction mixture is then heated
3. temperatureat reflux for 3 hrs
4. customreaction
5. temperatureto cool
6. filtrationThe product is collected by filtration
7. washwashed with water and melts at 154°-155° C.