m-Chloroperbenzoic acid → (11beta)-16-Chloro-17-(ethylsulfinyl)-9-fluoro-11-hydroxyandrosta-1,4,16-trien-3-one

Participants

Reaction Steps

To (11β)-16-chloro-17-(ethylthio)-9-fluoro-11-hydroxyandrosta-1,4,16-trien-3-one (100 mg; see Example 1A) in dichloromethane (15 ml) is added a solution of 85% m-chloroperbenzoic acid (56 mg) in dichloromethane (5.0 ml) over a period of 2 minutes. After 1 hour the solution is washed with a dilute sodium carbonate solution and water, dried (anhydrous MgSO4) and evaporated to yield the title compound.

Provenance & Evidence