Water → HCID 23463047, compound

HRID 2286340Notes

Reaction equation

HRID 2286340 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[S:13][C:12]2=[N:14][C:15]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[CH:16][N:11]2[N:10]=1)#N.[OH2:23].[OH:24]P(O)(O)=O>>[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[S:13][C:12]2=[N:14][C:15]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[CH:16][N:11]2[N:10]=1)([OH:24])=[O:23]

Participants

4

Reactant 3

HCID 962WaterHCID 1004Phosphoric AcidHCID 23463084HCID 23463084, compound

Product 1

HCID 23463047HCID 23463047, compound

Procedure

12 g of 2-(2-cyanophenyl)-6-phenyl-imidazo[2,1-b]-1,3,4-thiadiazole (Example No. 31) are heated to 170°-175° C. in 40 g of crystalline H3PO4 for 5 hours, the mixture is cooled and stirred with water, the precipitate is filtered off and dissolved in 2 N NaOH, the solution is clarified with charcoal and the product is precipitated with 2 N HCl.

Workup

  1. temperaturethe mixture is cooled
  2. filtrationthe precipitate is filtered off
  3. dissolutiondissolved in 2 N NaOH
  4. customthe product is precipitated with 2 N HCl

Sources & evidence

ORD record
ord-c2dc3cb32a8243958dd4575478e30cd8
Source dataset
uspto-grants-1981_05
Patent number
US04265898

Reaction notes

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