HCID 13338331, compound → HCID 13338332, compound

HRID 2286398Notes

Reaction equation

HRID 2286398 reaction equation
[Cl:1][C:2]1[C:12]2[CH2:11][CH2:10][N:9]([CH3:13])[CH2:8][CH2:7][C:6]=2[C:5]([N+:14]([O-])=O)=[CH:4][CH:3]=1.[H][H]>[Pt](=O)=O.C(O)C>[NH2:14][C:5]1[C:6]2[CH2:7][CH2:8][N:9]([CH3:13])[CH2:10][CH2:11][C:12]=2[C:2]([Cl:1])=[CH:3][CH:4]=1

Participants

5

Reactant 2

HCID 13338331HCID 13338331, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 13338332HCID 13338332, compound

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 702EthanolSolvent

Procedure

A suspension of 12.0 g. (0.05 mole) of 6-chloro-3-methyl-9-nitro-2,3,4,5-tetrahydro-1H-3-benzazepine, 100 ml. of ethanol and 0.2 g. of platinum dioxide is hydrogenated on a Parr apparatus at 25° C. and an initial hydrogen pressure of 60 p.s.i. After the rapid hydrogen uptake is completed, the mixture is filtered and the filtrate is concentrated in vacuo to give 9-amino-6-chloro-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine.

Workup

  1. additionA suspension of 12.0 g
  2. customis hydrogenated on a Parr apparatus at 25° C.
  3. filtrationthe mixture is filtered
  4. concentrationthe filtrate is concentrated in vacuo

Sources & evidence

ORD record
ord-24eac121dde04f8b84dd1d376a81a7f0
Source dataset
uspto-grants-1981_05
Patent number
US04265890

Reaction notes

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