Acetic Anhydride → HCID 23462861, compound

HRID 2286399Notes

Reaction equation

HRID 2286399 reaction equation
[NH2:1][C:2]1[C:7]2[CH2:8][CH2:9][N:10]([CH3:13])[CH2:11][CH2:12][C:6]=2[C:5]([Cl:14])=[CH:4][CH:3]=1.[C:15](OC(=O)C)(=[O:17])[CH3:16].[OH-].[Na+]>>[C:15]([NH:1][C:2]1[C:7]2[CH2:8][CH2:9][N:10]([CH3:13])[CH2:11][CH2:12][C:6]=2[C:5]([Cl:14])=[CH:4][CH:3]=1)(=[O:17])[CH3:16]

Participants

4

Reactant 3

HCID 7918Acetic AnhydrideHCID 14798Sodium HydroxideHCID 13338332HCID 13338332, compound

Product 1

HCID 23462861HCID 23462861, compound

Conditions

Temperature
25 °C

Procedure

A mixture of 10.5 g. (0.05 mole) of 9-amino-6-chloro-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and 50 ml. of acetic anhydride is stirred and heated at 60°-65° C. for 4 hours. The resulting solution is poured into ice/water and stirred at 25° C. for 16 hours, then it is made alkaline by addition of sodium hydroxide at 5°-10° C. The precipitate is immediately filtered to give 9-acetamido-6-chloro-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine.

Workup

  1. additionA mixture of 10.5 g
  2. temperatureheated at 60°-65° C. for 4 hours
  3. filtrationThe precipitate is immediately filtered

Sources & evidence

ORD record
ord-6cbb7e9a273e4aa887604d2792c28c55
Source dataset
uspto-grants-1981_05
Patent number
US04265890

Reaction notes

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