Acetic Anhydride → HCID 23462861, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 10.5 g. (0.05 mole) of 9-amino-6-chloro-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and 50 ml. of acetic anhydride is stirred and heated at 60°-65° C. for 4 hours. The resulting solution is poured into ice/water and stirred at 25° C. for 16 hours, then it is made alkaline by addition of sodium hydroxide at 5°-10° C. The precipitate is immediately filtered to give 9-acetamido-6-chloro-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine.

Provenance & Evidence