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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2286405Generated: October 26, 2026

Acetyl bromide → 8-acetoxy-7-methoxy-3-methyl-6-phenylthio-2,3,4,5-tetrahydro-1H-3-benzazepine

https://huagongshe.com/reaction/2286405

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAcetyl bromideHCID 10482—
Reactant8-hydroxy-7-methoxy-3-methyl-6-phenylthio-2,3,4,5-tetrahydro-1H-3-benzazepineHCID 23462859—
SolventTrifluoroacetic acidHCID 6422—
Product8-acetoxy-7-methoxy-3-methyl-6-phenylthio-2,3,4,5-tetrahydro-1H-3-benzazepineHCID 23462857—

Reaction Steps

Reaction of 8-hydroxy-7-methoxy-3-methyl-6-phenylthio-2,3,4,5-tetrahydro-1H-3-benzazepine with acetyl bromide in trifluoroacetic acid gave 8-acetoxy-7-methoxy-3-methyl-6-phenylthio-2,3,4,5-tetrahydro-1H-3-benzazepine; hydrochloride salt m.p. 240°-241° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04265890
Source datasetuspto-grants-1981_05
ORD IDord-704c5718465a458385efaf690c975bc5
Source noteuspto-grants-1981_05