Ethyl 3-(m-nitrophenyl)-3-oxopropionate → HCID 23463335, compound

HRID 2286421Notes

Reaction equation

HRID 2286421 reaction equation
C(O[C:4](=[O:17])[CH2:5][C:6](=O)[C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([N+:13]([O-:15])=[O:14])[CH:8]=1)C.O.[F:19][C:20]([F:25])([F:24])[CH2:21][NH:22][NH2:23]>C(O)(=O)C.O>[F:19][C:20]([F:25])([F:24])[CH2:21][N:22]1[C:4](=[O:17])[CH2:5][C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([N+:13]([O-:15])=[O:14])[CH:8]=2)=[N:23]1

Participants

5

Reactant 2

HCID 104078Ethyl 3-(m-nitrophenyl)-3-oxopropionateHCID 23463329HCID 23463329, compound

Product 1

HCID 23463335HCID 23463335, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Procedure

0.15 Mole (35.6 g) of m-nitrobenzoyl acetic acid ethyl ester and 0.15 mole (25.2 g) of 2,2,2-trifluoroethyl hydrazine hydrate were stirred together for 2 hours in 90 ml of boiling acetic acid. Subsequently, the reaction mixture was poured out in water. After stirring and filtration, the precipitate was recrystallized from methanol.

Workup

  1. filtrationfiltration
  2. customthe precipitate was recrystallized from methanol

Sources & evidence

ORD record
ord-fcb5fd1a657f49cda5934042f48a6c2b
Source dataset
uspto-grants-1981_05
Patent number
US04266014

Reaction notes

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