2,6-Dimethylaniline → HCID 70545454, compound

HRID 2286448Notes

Reaction equation

HRID 2286448 reaction equation
[C:1](/[C:3](=[C:12](/OCC)\[CH3:13])/[C:4]([NH:6][C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5])#[N:2].[CH3:17][C:18]1[CH:24]=[CH:23][CH:22]=[C:21]([CH3:25])[C:19]=1[NH2:20]>C(O)C>[C:1](/[C:3](=[C:12](/[NH:20][C:19]1[C:21]([CH3:25])=[CH:22][CH:23]=[CH:24][C:18]=1[CH3:17])\[CH3:13])/[C:4]([NH:6][C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5])#[N:2]

Participants

4

Reactant 2

HCID 68962,6-DimethylanilineHCID 16103528HCID 16103528, compound

Product 1

HCID 70545454HCID 70545454, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

α-Cyano-β-ethoxy-N-ethoxycarbonylcrotonamide (0.05 mol) is reacted with 2,6-dimethylaniline (0.05 mol) in hot ethanol using the procedure of Example 1 to yield α-cyano-β-(2,6-dimethylanilino)-N-ethoxycarbonylcrotonamide, which is cyclized by heating in tetralin to yield 5-cyano-1-(2,6-dimethylphenyl)-6-methyluracil, m.p. 302°-303°.

Sources & evidence

ORD record
ord-16d4d7ad14fa4cc4851e063c58309a3b
Source dataset
uspto-grants-1981_05
Patent number
US04266056

Reaction notes

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