HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aniline → 2,4-Dioxo-1-phenyl-1,2,3,4-tetrahydropyrimidine-5-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aniline | HCID 6115 | — |
| Reactant | 4-Bromoaniline | HCID 7807 | — |
| Reactant | ethyl N-(2-cyano-3-ethoxyacryloyl)carbamate | HCID 230015 | — |
| Product | 2,4-Dioxo-1-phenyl-1,2,3,4-tetrahydropyrimidine-5-carbonitrile | HCID 235105 | — |
| Product | 5-Cyano-1-(4-bromophenyl)uracil | HCID 13014496 | — |
Reaction Steps
Following procedures hereinabove, each of aniline and 4-bromoaniline is reacted with α-cyano-β-ethoxy-N-ethoxycarbonylacrylamide and cyclized to yield 5-cyano-1-phenyluracil, m.p. 290°, and 5-cyano-1-(4-bromophenyl)uracil, m.p. 257°-260°. The foregoing two compounds have been reported by Atkinson et al., J. Chem. Soc. 4118-4123 (1956) and Senda et al., Chem Pharm. Bull. 22(1), 189-195 (1974), respectively.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04266056 |
| Source dataset | uspto-grants-1981_05 |
| ORD ID | ord-e3014f88f4724b5bbc1486ecaa6cff61 |
| Source note | uspto-grants-1981_05 |