Water → Hydroxy(thiophen-2-yl)acetic acid

HRID 2286458Notes

Reaction equation

[OH-:1].[Na+].Br[CH:4](Br)[C:5]([C:7]1[S:8][CH:9]=[CH:10][CH:11]=1)=[O:6].[OH2:13]>>[S:8]1[CH:9]=[CH:10][CH:11]=[C:7]1[CH:5]([OH:6])[C:4]([OH:13])=[O:1]

Participants

Reactant 3

HCID 962Water

HCID 14798Sodium Hydroxide

HCID 8188792,2-Dibromo-1-(thiophen-2-yl)ethan-1-one

Product 1

HCID 349855Hydroxy(thiophen-2-yl)acetic acidYield 77%

Procedure

The reaction was performed in the same manner as in Example 4 except that a solution of 8.0 g (200 mmol) of sodium hydroxide in 90 ml of water was used and 14.2 g (50 mmol) of 2-(dibromoacetyl)thiophene was used, gave 5.6 g of 2-thiopheneglycolic acid (yield: 77%).

Sources & evidence

ORD record: ord-9586a7e4024146e8a3cc7629dbc232f9
Source dataset: uspto-grants-1981_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04266067

Reaction notes

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