反应详情

A mixture of 100 millimoles of diethyl 2-(3-fluoro-4-nitrophenyl)-2-methylmalonate, 110 millimoles of sodium chloride and 50 milliliters of dimethyl sulfoxide is heated under nitrogen at about 130° to 180° C. for about 6 hours. On cooling the mixture is diluted with 100 milliliters of water and 100 milliliters of ethyl acetate. The layers are separated and the organic layer is washed two times with 25 milliliters of water. After drying over disodium sulfate the organic layer is concentrated in vacuo to give the desired ethyl 2-(3-fluoro-4-nitrophenyl)propionate.

1. temperatureis heated under nitrogen at about 130° to 180° C. for about 6 hours
2. temperatureOn cooling the mixture
3. customThe layers are separated
4. washthe organic layer is washed two times with 25 milliliters of water
5. dry with materialAfter drying over disodium sulfate the organic layer
6. concentrationis concentrated in vacuo