HCID 15573111, compound → HCID 15573111, compound

HRID 2286494Notes

Reaction equation

HRID 2286494 reaction equation
[CH3:1][O:2][CH:3]([C:6]1[C:7]([NH2:22])=[N:8][C:9](=[O:21])[N:10]([CH:20]=1)[C@@H:11]1[O:19][C@H:16]([CH2:17][OH:18])[C@@H:14]([OH:15])[C@H:12]1[OH:13])[CH2:4][CH3:5]>Cl>[CH3:1][O:2][CH:3]([C:6]1[C:7]([NH2:22])=[N:8][C:9](=[O:21])[N:10]([CH:20]=1)[C@@H:11]1[O:19][C@H:16]([CH2:17][OH:18])[C@@H:14]([OH:15])[C@H:12]1[OH:13])[CH2:4][CH3:5].[OH:2][CH:3]([C:6]1[C:7]([NH2:22])=[N:8][C:9](=[O:21])[N:10]([CH:20]=1)[C@@H:11]1[O:19][C@H:16]([CH2:17][OH:18])[C@@H:14]([OH:15])[C@H:12]1[OH:13])[CH2:4][CH3:5]

Participants

4

Reactant 1

HCID 15573111HCID 15573111, compound

Product 2

HCID 15573111HCID 15573111, compoundHCID 53756957HCID 53756957, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

5-(1-Methoxyprop-1-yl)cytidine (315 mg, 1 mmol) in 10 ml 0.05 N HCl is stirred for approximately 48 hours at about 30° C. Column chromatography of the reaction mixture on molecular exclusion resin eluting with water affords 5-(1-methoxyprop-1-yl)cytidine and 5-(1-hydroxyprop-1-yl)cytidine.

Workup

  1. washColumn chromatography of the reaction mixture on molecular exclusion resin eluting with water

Sources & evidence

ORD record
ord-9a972434f69a499483d735d119113876
Source dataset
uspto-grants-1981_05
Patent number
US04267171

Reaction notes

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