HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Fluoride → 5-Fluoro-N-isopropylpyrimidin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Fluoride | HCID 522689 | — |
| Reactant | 5-Bromo-2-(isopropylamino)pyrimidine | HCID 16427110 | — |
| Product | 5-Fluoro-N-isopropylpyrimidin-2-amine | HCID 23461723 | 83% |
Reaction Steps
Stoichiometric proportions of 2-isopropylamino-5-bromo-pyrimidine, prepared as described in example 1, and potassium fluoride were reacted together for 5 hours. After appropriate working up, the title compound was obtained as a white powder in a yield of 83%. Elemental analysis showed that the compound had the expected empirical formula of C7H10N3F.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04267181 |
| Source dataset | uspto-grants-1981_05 |
| ORD ID | ord-81d3faac23584c64b4401be39246cbfa |
| Source note | uspto-grants-1981_05 |