Potassium Fluoride → 5-Fluoro-N-isopropylpyrimidin-2-amine

HRID 2286499Notes

Reaction equation

HRID 2286499 reaction equation
[CH:1]([NH:4][C:5]1[N:10]=[CH:9][C:8](Br)=[CH:7][N:6]=1)([CH3:3])[CH3:2].[F-:12].[K+]>>[CH:1]([NH:4][C:5]1[N:10]=[CH:9][C:8]([F:12])=[CH:7][N:6]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 522689Potassium FluorideHCID 164271105-Bromo-2-(isopropylamino)pyrimidine

Product 1

HCID 234617235-Fluoro-N-isopropylpyrimidin-2-amineYield 83%

Procedure

Stoichiometric proportions of 2-isopropylamino-5-bromo-pyrimidine, prepared as described in example 1, and potassium fluoride were reacted together for 5 hours. After appropriate working up, the title compound was obtained as a white powder in a yield of 83%. Elemental analysis showed that the compound had the expected empirical formula of C7H10N3F.

Workup

  1. customwere reacted together for 5 hours

Sources & evidence

ORD record
ord-81d3faac23584c64b4401be39246cbfa
Source dataset
uspto-grants-1981_05
Patent number
US04267181

Reaction notes

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