Aluminium lithium hydride → 4-(3-Methylbutyl)piperazin-1-amine

HRID 2286512Notes

Reaction equation

HRID 2286512 reaction equation
[CH3:1][CH:2]([CH3:13])[CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][N:8]([N:11]=O)[CH2:7][CH2:6]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[CH3:1][CH:2]([CH3:13])[CH2:3][CH2:4][N:5]1[CH2:6][CH2:7][N:8]([NH2:11])[CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 234616511-(3-Methylbutyl)-4-nitrosopiperazine

Product 1

HCID 234616824-(3-Methylbutyl)piperazin-1-amineYield 90.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

A solution of N-(3-methyl-butyl)-N'-nitrosopiperazine (3 g.) in anhydrous tetrahydrofuran (30 ml). was added dropwise to a stirred suspension of lithium aluminium hydride (0.65 g.) in anhydrous tetrahydrofuran (100 ml.) under nitrogen at 50°. After 30 minutes, the mixture was cooled and worked up in the usual manner to give crude N-(3-methylbutyl)-N'-amino-piperazine (2.5 g.) used without purification in the next step.

Workup

  1. temperaturethe mixture was cooled

Sources & evidence

ORD record
ord-c9dde59af790430892c7f48c8c4c8770
Source dataset
uspto-grants-1981_05
Patent number
US04267175

Reaction notes

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