反应详情

A mixture of 47.8 parts of 1-(4-isothiocyanatophenyl)-4-(4-methoxyphenyl)piperazine, 100 parts of hydrazine hydrate and 400 parts of 1,4-dioxane is stirred and refluxed for 1 hour. The reaction mixture is cooled and poured onto water. The precipitated product is filtered off, washed with water and with methanol and dried, yielding 46 parts (89%) of N-{4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl}hydrazinecarbothioamide.

1. temperaturerefluxed for 1 hour
2. temperatureThe reaction mixture is cooled
3. additionpoured onto water
4. filtrationThe precipitated product is filtered off
5. washwashed with water and with methanol
6. customdried