Hydrochloric Acid → HCID 178433555, compound

HRID 2286546Notes

Reaction equation

HRID 2286546 reaction equation
[NH2:1][C:2](=[S:17])[NH:3][N:4]([C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[CH:10][CH:9]=1)[C:5](=O)[CH3:6].Cl>[OH-].[Na+].O>[CH3:6][C:5]1[N:4]([C:8]2[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[CH:10][CH:9]=2)[N:3]=[C:2]([SH:17])[N:1]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 15581904HCID 15581904, compound

Product 1

HCID 178433555HCID 178433555, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 14798Sodium HydroxideSolvent

Procedure

40 Parts of acetic acid, 2-(aminothioxomethyl)-1-(4-nitrophenyl)hydrazide are dissolved in a mixture of 10 parts of sodium hydroxide and 400 parts of water and the solution is stirred for 30 minutes at room temperature. The reaction mixture is acidified with concentrated hydrochloric acid. The precipitated product is filtered off, washed with water and with 2-propanol and crystallized from 1,4-dioxane, yielding 22.4 parts of 5-methyl-1-(4-nitrophenyl)-1H-1,2,4-triazole-3-thiol; mp. 202.1° C.

Workup

  1. filtrationThe precipitated product is filtered off
  2. washwashed with water and with 2-propanol
  3. customcrystallized from 1,4-dioxane

Sources & evidence

ORD record
ord-8d5b195950a24b459bc29ff98b6aeb02
Source dataset
uspto-grants-1981_05
Patent number
US04267179

Reaction notes

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