反应详情

A mixture of 30 parts of 4-[4-(4-methoxyphenyl)-1-piperazinyl]benzenamine and 300 parts of a hydrobromic acid solution 48% in water is stirred and refluxed for 10 days. The reaction mixture is evaporated and the residue is alkalized with sodium hydroxide. The mixture is filtered and the filtrate is acidified with acetic acid. The precipitated product is filtered off and crystallized from 1,4-dioxane, yielding 12 parts (44%) of 4-[4-(4-aminophenyl)-1-piperazinyl]phenol.

1. temperaturerefluxed for 10 days
2. customThe reaction mixture is evaporated
3. filtrationThe mixture is filtered
4. filtrationThe precipitated product is filtered off
5. customcrystallized from 1,4-dioxane