HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-(2-Carboxyethyl)-2,6-Dimethyl-4-(Hexafluoro-2-Hydroxy-2-Propyl)Aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | HCID 15572220 | HCID 15572220 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | N-(2-Carboxyethyl)-2,6-Dimethyl-4-(Hexafluoro-2-Hydroxy-2-Propyl)Aniline | HCID 15572234 | — |
Reaction Steps
Combine N-(2-cyanoethyl)-2,6-dimethyl-4-(hexafluoro-2-hydroxy-2-propyl)aniline (4.0 g, 12 mmol) with 350 ml 1.0 N NaOH. Reflux 2 hours, allow to cool, add concentrated HCl, and then solid NaHCO3. Extract with ether, dry and concentrate. Recrystallize from ether-hexane to give title compound as a solid product, m.p. 175°-176° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04267193 |
| Source dataset | uspto-grants-1981_05 |
| ORD ID | ord-95b92b49fc7e4ca4a51689edfadbf7ca |
| Source note | uspto-grants-1981_05 |