反应详情

Combine N-(2-cyanoethyl)-2,6-dimethyl-4-(hexafluoro-2-hydroxy-2-propyl)aniline (4.0 g, 12 mmol) with 350 ml 1.0 N NaOH. Reflux 2 hours, allow to cool, add concentrated HCl, and then solid NaHCO3. Extract with ether, dry and concentrate. Recrystallize from ether-hexane to give title compound as a solid product, m.p. 175°-176° C.

1. temperatureReflux 2 hours
2. temperatureto cool
3. extractionExtract with ether
4. customdry
5. concentrationconcentrate
6. customRecrystallize from ether-hexane