Hydrochloric Acid → HCID 15572237, compound

HRID 2286602Notes

Reaction equation

HRID 2286602 reaction equation
C([O:3][C:4]([CH2:6][NH:7][C:8]1[C:13]([CH3:14])=[CH:12][C:11]([C:15]([OH:24])([C:20]([F:23])([F:22])[Cl:21])[C:16]([F:19])([F:18])[Cl:17])=[CH:10][C:9]=1[CH3:25])=[O:5])C.Cl>[OH-].[Na+]>[C:4]([CH2:6][NH:7][C:8]1[C:13]([CH3:14])=[CH:12][C:11]([C:15]([OH:24])([C:20]([F:23])([F:22])[Cl:21])[C:16]([F:18])([F:19])[Cl:17])=[CH:10][C:9]=1[CH3:25])([OH:5])=[O:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15572233HCID 15572233, compound

Product 1

HCID 15572237HCID 15572237, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

Dissolve the ethyl ester of Example 8 (3.0 g=7.4 mmol) in 70 ml 1.0 N NaOH. After 30 minutes acidify with concentrated HCl to pH 4. Extract the product with Et2O, dry and concentrate. Recrystallize from Et2O-hexane to obtain the title product as a white solid, melting at about 139°-142° (dec.)

Workup

  1. extractionExtract the product with Et2O
  2. customdry
  3. concentrationconcentrate
  4. customRecrystallize from Et2O-hexane

Sources & evidence

ORD record
ord-d93e58d586a843c1bc097428b3794444
Source dataset
uspto-grants-1981_05
Patent number
US04267193

Reaction notes

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