Hydrochloric Acid → 2-(6-Aminopyridin-2-yl)-2-methoxyiminoacetic acid hydrochloride

HRID 2286650Notes

Reaction equation

HRID 2286650 reaction equation
C([NH:3][C:4]1[N:9]=[C:8]([C:10](=[N:14][O:15][CH3:16])[C:11]([OH:13])=[O:12])[CH:7]=[CH:6][CH:5]=1)=O.[ClH:17]>CO>[ClH:17].[NH2:3][C:4]1[N:9]=[C:8]([C:10](=[N:14][O:15][CH3:16])[C:11]([OH:13])=[O:12])[CH:7]=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 543262512-(6-Formamidopyridin-2-yl)-2-methoxyiminoacetic acid

Product 1

HCID 867377252-(6-Aminopyridin-2-yl)-2-methoxyiminoacetic acid hydrochlorideYield 104.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of 2(6-formamidopyridin-2-yl)-2-methoxyiminoacetic acid (1.5 g.) and conc. hydrochloric acid (0.77 g.) in methanol (30 ml.) was stirred at room temperature for 45 minutes. After concentrating the resultant solution under reduced pressure, the residue was washed with diethyl ether. The precipitates were collected by filtration to give 2-(6-aminopyridin-2-yl)-2-methoxyiminoacetic acid hydrochloride (1.63 g.), mp 100° to 105° C.

Workup

  1. concentrationAfter concentrating the resultant solution under reduced pressure
  2. washthe residue was washed with diethyl ether
  3. filtrationThe precipitates were collected by filtration

Sources & evidence

ORD record
ord-c9e9af850c8843e49aacce79cd1f95f5
Source dataset
uspto-grants-1981_05
Patent number
US04267176

Reaction notes

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