Maleic Acid → HCID 12875599, compound

HRID 2286686Notes

Reaction equation

HRID 2286686 reaction equation
[C:1]1([CH:7]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[N:8]2[CH2:13][CH2:12][CH:11]([NH:14][CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[N:17]=3)[CH2:10][CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:29]([OH:36])(=[O:35])/[CH:30]=[CH:31]\[C:32]([OH:34])=[O:33]>C(OCC)C>[C:29]([OH:36])(=[O:35])/[CH:30]=[CH:31]\[C:32]([OH:34])=[O:33].[C:23]1([CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[N:8]2[CH2:13][CH2:12][CH:11]([NH:14][CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[N:17]=3)[CH2:10][CH2:9]2)[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

Participants

4

Reactant 2

HCID 444266Maleic AcidHCID 12875598HCID 12875598, compound

Product 1

HCID 12875599HCID 12875599, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

6 Parts of 1-(diphenylmethyl)-N-[(6-methyl-2-pyridyl)methyl]-4-piperidinamine is dissolved in 150 parts by volume of ethyl ether and to this solution is added 100 parts by volume of the saturated solution of maleic acid in ethyl ether. The resultant mixture is filtered, the solid washed three times with 100 parts by volume portions of ethyl ether and dried in vacuo overnight at 85° C. to yield 1-(diphenylmethyl)-N-[(6-methyl-2-pyridyl)methyl]-4-piperidinamine maleate, as colorless needless melting at about 190°-191° C. after recystallization from acetonitrile. This compound has the following structural formula. ##STR36##

Workup

  1. filtrationThe resultant mixture is filtered
  2. washthe solid washed three times with 100 parts by volume portions of ethyl ether
  3. customdried in vacuo overnight at 85° C.

Sources & evidence

ORD record
ord-acd9ecc0c2b042c9b9cbe7ff3224f831
Source dataset
uspto-grants-1981_05
Patent number
US04267318

Reaction notes

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