Methanesulfonyl chloride → HCID 10878028, compound

HRID 2286762Notes

Reaction equation

HRID 2286762 reaction equation
[CH3:1][C:2]([CH3:8])([CH2:6][OH:7])[C:3](=[O:5])[CH3:4].[CH3:9][S:10](Cl)(=[O:12])=[O:11]>N1C=CC=CC=1.C(Cl)Cl>[CH3:9][S:10]([O:7][CH2:6][C:2]([CH3:8])([CH3:1])[C:3](=[O:5])[CH3:4])(=[O:12])=[O:11]

Participants

5

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 111943184-Hydroxy-3,3-dimethylbutan-2-one

Product 1

HCID 10878028HCID 10878028, compoundYield 86%

Reagents, catalysts & solvents 2

HCID 1049PyridineSolventHCID 6344DichloromethaneSolvent

Procedure

232 g (2 mol) of 3,3-dimethyl-4-hydroxy-2-butanone (for the preparation, see Beilstein H 1 E III 3239, IV 4030 and Bull. Soc. Chim. France 1964, 2849) were reacted in 700 ml of absolute pyridine at 0° to 5° C. with 229 g (2 mol) of methanesulphonyl chloride. After standing for 12 hours at 20° C., the reaction mixture was diluted with methylene chloride and extracted by shaking with ice-water. The organic phase was dried, freed from solvent in vacuo and fractionated through a column. At a boiling point of 106° to 120° C./0.12 mm Hg, 332 g (that is to say 86% of theory) of 2,2-dimethyl-3-oxo-butyl methanesulphonate were isolated. ##STR10##

Workup

  1. extractionextracted
  2. customThe organic phase was dried

Sources & evidence

ORD record
ord-a9859d3576e347d1b09e48b0ce0a56e1
Source dataset
uspto-grants-1981_05
Patent number
US04267381

Reaction notes

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