Methanesulfonyl chloride → HCID 10878028, compound

Participants

Reaction Steps

232 g (2 mol) of 3,3-dimethyl-4-hydroxy-2-butanone (for the preparation, see Beilstein H 1 E III 3239, IV 4030 and Bull. Soc. Chim. France 1964, 2849) were reacted in 700 ml of absolute pyridine at 0° to 5° C. with 229 g (2 mol) of methanesulphonyl chloride. After standing for 12 hours at 20° C., the reaction mixture was diluted with methylene chloride and extracted by shaking with ice-water. The organic phase was dried, freed from solvent in vacuo and fractionated through a column. At a boiling point of 106° to 120° C./0.12 mm Hg, 332 g (that is to say 86% of theory) of 2,2-dimethyl-3-oxo-butyl methanesulphonate were isolated. ##STR10##

Provenance & Evidence