反应详情

Using the method described in Example 1, last paragraph, 25.0 g (0.129 mole) of 4-acetoxy-2,3,5-trimethylphenol were reacted with 12.3 g (0.129 mole) of methyl vinyl ketone cyanohydrin, stabilized with phosphoric acid, and with 13.3 g (0.129 mole) of BF3. Conventional working up of the reaction mixture gave, according to analysis by gas chromatography, 25% of 6-acetoxy-2,5,7,8-tetramethyl-2-cyanochromane; colorless crystals, melting point 149°-151° C. In addition, 15% of 6-hydroxy-2,5,7,8-tetramethyl-2-cyanochromane were obtained.

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