反应详情

A mixture of 5.4 g (20 mmol) of diethyl 4-phenylbutylphosphonate (Compound 11, synthesized exactly by the same method described in Example 5) and 14 g of 37% hydrochloric acid was refluxed for five hours. The excess of acid was removed under vacuum leaving an oil that slowly solidified Recrystallization from an ethanol:petroleum ether (40:60) mixture gave 1.7 g (8 mmol) of white crystals.

1. customsynthesized exactly by the same method
2. temperaturewas refluxed for five hours
3. customThe excess of acid was removed under vacuum
4. customleaving
5. customan oil that slowly solidified Recrystallization from an ethanol:petroleum ether (40:60) mixture