Phosgene → HCID 21790708, compound

HRID 2286841Notes

Reaction equation

HRID 2286841 reaction equation
[NH2:1][C:2]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:3]=1[C:4]([NH:6][N:7]1[CH2:12][CH2:11][O:10][CH2:9][CH2:8]1)=[O:5].[C:18](Cl)(Cl)=[O:19]>Cl>[Cl:17][C:14]1[CH:13]=[C:3]2[C:2](=[CH:16][CH:15]=1)[NH:1][C:18](=[O:19])[N:6]([N:7]1[CH2:8][CH2:9][O:10][CH2:11][CH2:12]1)[C:4]2=[O:5]

Participants

4

Reactant 2

HCID 6371PhosgeneHCID 13776542HCID 13776542, compound

Product 1

HCID 21790708HCID 21790708, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

23.5 g 2-Amino-5-chloro-N-morpholinobenzamide are dissolved in 500 cc 2N hydrochloric acid. A phosgene stream is passed through the solution for 1 hour. When the reaction is complete, the equipment is purged, after which the resulting material is suction filtered and washed with water. It is purified by crystallization from ethanol, M.P.=335° C.

Workup

  1. customthe equipment is purged
  2. filtrationfiltered
  3. washwashed with water
  4. customIt is purified by crystallization from ethanol, M.P.=335° C.

Sources & evidence

ORD record
ord-7122b0dedce447b7a76e381c6b5e2f9d
Source dataset
uspto-grants-1981_05
Patent number
US04268511

Reaction notes

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