反应详情

温度

0 °C

In a 50 ml. round bottom flask under nitrogen was placed 2-(p-chlorophenyl)-1,2,3,4-tetrahydro[1]benzothiopyrano[4,3-c]pyrazole-3-one (0.5 g., 0.0016 mole) 8.33 ml. of glacial acetic acid and 3 ml. of 30% hydrogen peroxide. After stirring at 0° C., for 3.5 hours, the resulting solid was removed by filtration, washed with glacial acetic acid and dried in vacuo over phosphorous pentoxide to afford product, m.p. 193° C. (dec.). Weight 0.42 g. (80%). A second crop (0.4 g., 8%) was obtained from mother liquors.

1. customround bottom flask under nitrogen was placed
2. customthe resulting solid was removed by filtration
3. washwashed with glacial acetic acid
4. dry with materialdried in vacuo over phosphorous pentoxide
5. customto afford product, m.p. 193° C. (dec.)
6. customA second crop (0.4 g., 8%) was obtained from mother liquors