Chloral → HCID 23460490, compound

HRID 2286856Notes

Reaction equation

HRID 2286856 reaction equation
[NH2:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][OH:5].O=[CH:11][C:12]([Cl:15])([Cl:14])[Cl:13]>C1(C)C=CC=CC=1>[Cl:13][C:12]([Cl:15])([Cl:14])[CH:11]1[NH:1][C:2]2[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=2[CH2:4][O:5]1

Participants

4

Reactant 2

HCID 6407ChloralHCID 214392-Aminobenzyl alcohol

Product 1

HCID 23460490HCID 23460490, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of o-aminobenzyl alcohol (2.4 g.) in toluene (5 ml.) was stirred at ambient temperature while anhydrous chloral (2.0 ml.) was added dropwise. The mixture was stirred for 30 minutes, and evaporated to dryness to yield an oil, which was crystallised from aqueous ethanol to give 1,2-dihydro-2-trichloromethyl-4H-benzo[d]-[1,3]-oxazine, m.p. 90°-92° C.

Workup

  1. additionwas added dropwise
  2. customevaporated to dryness
  3. customto yield an oil, which
  4. customwas crystallised from aqueous ethanol

Sources & evidence

ORD record
ord-460600a357094b5e93afb6ce2c7300ff
Source dataset
uspto-grants-1981_05
Patent number
US04268510

Reaction notes

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