Hydrochloric Acid → (5-Methoxy-2-nitrophenyl)methanol

HRID 2286858Notes

Reaction equation

HRID 2286858 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([N+:11]([O-:13])=[O:12])=[C:7]([CH:10]=1)[CH:8]=[O:9].[BH4-].[Na+].O.Cl>C(O)C>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([N+:11]([O-:13])=[O:12])=[C:7]([CH:10]=1)[CH2:8][OH:9]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 2303715-Methoxy-2-nitrobenzaldehydeHCID 4311764Sodium borohydride

Product 1

HCID 53405061(5-Methoxy-2-nitrophenyl)methanol

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 5-methoxy-2-nitrobenzaldehyde (2.3 g.) in ethanol (100 ml.) was stirred at ambient temperature, sodium borohydride (0.6 g.) was added and stirring was continued for 2 hours. Water (100 ml.) was added, and the solution was acidified with 2 N hydrochloric acid and extracted with ether (3×100 ml.). The extracts were combined and dried and the solvent was evaporated to give 5-methoxy-2-nitrobenzyl alcohol.

Workup

  1. extractionextracted with ether (3×100 ml.)
  2. customdried
  3. customthe solvent was evaporated

Sources & evidence

ORD record
ord-b4589d21db1b4ed8a505ae4a0e96a430
Source dataset
uspto-grants-1981_05
Patent number
US04268510

Reaction notes

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