Ethanol → HCID 23460471, compound

HRID 2286873Notes

Reaction equation

HRID 2286873 reaction equation
[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12]([OH:14])=[O:13])[CH:10]=2)[NH:5][CH:4]([C:15]([Cl:18])([Cl:17])[Cl:16])[NH:3]1.S(=O)(=O)(O)O.[CH2:24](O)[CH3:25]>>[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12]([O:14][CH2:24][CH3:25])=[O:13])[CH:10]=2)[NH:5][CH:4]([C:15]([Cl:18])([Cl:16])[Cl:17])[NH:3]1

Participants

4

Reactant 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 13341940HCID 13341940, compound

Product 1

HCID 23460471HCID 23460471, compound

Procedure

1,2-dihydro-4-oxo-2-trichloromethylquinazoline-6-carboxylic acid (0.5 g.), ethanol (6 ml.) and concentrated sulphuric acid (3 ml.) were heated together under reflux on a steam bath for 1.5 hours. The reaction mixture was filtered, and the filtrate was poured onto a minimum quantity of ice. The precipitate thus produced was filtered off, washed with water and dried, to give ethyl 1,2-dihydro-4-oxo-2-trichloromethylquinazoline-6-carboxylate, m.p. 243°-244° C.

Workup

  1. temperatureunder reflux on a steam bath for 1.5 hours
  2. filtrationThe reaction mixture was filtered
  3. additionthe filtrate was poured onto a minimum quantity of ice
  4. customThe precipitate thus produced
  5. filtrationwas filtered off
  6. washwashed with water
  7. customdried

Sources & evidence

ORD record
ord-2a86a4aaa1c84ad1b4f5ddfc29789a62
Source dataset
uspto-grants-1981_05
Patent number
US04268510

Reaction notes

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