Hydrochloride methanol → HCID 68828808, compound

HRID 228702Notes

Reaction equation

HRID 228702 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][C:17]=1[C:24](=[O:26])[CH3:25].[ClH:27].CO>>[ClH:27].[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][C:17]=1[C:24](=[O:26])[CH3:25]

Participants

3

Reactant 2

HCID 21893726Hydrochloride methanolHCID 24879270HCID 24879270, compound

Product 1

HCID 68828808HCID 68828808, compoundYield 10%

Procedure

1-[2-(6,7-Dimethoxy-quinolin-4-yloxy)-5-methoxy-phenyl]-ethanone (802 mg) was dissolved in a hydrochloric acid-methanol solution (20 ml) to prepare a solution which was then stirred at room temperature overnight. The solvent was removed by distillation under the reduced pressure, and the residue was washed with ethyl acetate and was dried in vacuo to give the title compound (885 mg, yield 10%).

Workup

  1. customto prepare a solution which
  2. customThe solvent was removed by distillation under the reduced pressure
  3. washthe residue was washed with ethyl acetate
  4. customwas dried in vacuo

Sources & evidence

ORD record
ord-dd4b7784496c484597ddfe3f571fcfa8
Source dataset
uspto-grants-2009_07
Patent number
US07560558B2

Reaction notes

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