4-(2-Chloroethyl)morpholine → 4-(3-piperazino)propyl-4H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-5(8H)-one

HRID 2287151Notes

Reaction equation

HRID 2287151 reaction equation
[N:1]1([CH2:7][CH2:8][CH2:9]Cl)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.ClCCN1CCOCC1.[N:20]1[N:24]2[C:25]3[C:33]4[CH:34]=[N:35][NH:36][C:32]=4[N:31]=[CH:30][C:26]=3[C:27](=[O:29])[NH:28][C:23]2=[N:22][CH:21]=1>>[N:1]1([CH2:7][CH2:8][CH2:9][N:28]2[C:27](=[O:29])[C:26]3[CH:30]=[N:31][C:32]4[NH:36][N:35]=[CH:34][C:33]=4[C:25]=3[N:24]3[N:20]=[CH:21][N:22]=[C:23]23)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 767274-(2-Chloroethyl)morpholineHCID 5776061-(3-Chloropropyl)piperazineHCID 1355938534H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-5(8H)-one

Product 1

HCID 234595844-(3-piperazino)propyl-4H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-5(8H)-one

Procedure

By substituting 3-piperazinopropyl chloride for the 1-chloro-2-morpholinoethane in the procedure of Example 8 and utilizing the 4H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-5(8H)-one product of Example 11, 4-(3-piperazino)propyl-4H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-5(8H)-one is obtained.

Sources & evidence

ORD record
ord-19214faf19be43a1b0f0fba8751de0e9
Source dataset
uspto-grants-1981_05
Patent number
US04269836

Reaction notes

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