HCID 13017518, compound → HCID 13017519, compound

HRID 2287223Notes

Reaction equation

HRID 2287223 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]3[N:10]([CH:14]=[N:15][N:16]=3)[CH:11]=[N:12][CH:13]=2)=[CH:4][CH:3]=1>CO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]3[N:16]([N:15]=[CH:14][N:10]=3)[CH:11]=[N:12][CH:13]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 13017518HCID 13017518, compound

Product 1

HCID 13017519HCID 13017519, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 1.76 g. of 8-(4-chlorophenyl)-1,2,4-triazolo[4,3-c]pyrimidine and 25 ml. of methanol is heated at the reflux temperature for 18 hours. The reaction mixture is cooled to room temperature to separate a crystalline material which is collected by filtration to give 1.53 g. (83%) of the product of the example, m.p. 154°-155° C.

Workup

  1. additionA mixture of 1.76 g
  2. customto separate a crystalline material which
  3. filtrationis collected by filtration
  4. customto give 1.53 g

Sources & evidence

ORD record
ord-b7a73640808f40fdacaf73a442dde3aa
Source dataset
uspto-grants-1981_05
Patent number
US04269980

Reaction notes

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