Benzene → HCID 12879910, compound

HRID 2287248Notes

Reaction equation

HRID 2287248 reaction equation
C1C=CC=CC=1.[C:7]1([C:13]2([NH2:18])[CH2:17][CH2:16][CH2:15][CH2:14]2)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[Cl:19][C:20]([Cl:25])([Cl:24])[C:21](Cl)=[O:22]>C(N(CC)CC)C>[C:7]1([C:13]2([NH:18][C:21](=[O:22])[C:20]([Cl:25])([Cl:24])[Cl:19])[CH2:17][CH2:16][CH2:15][CH2:14]2)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

5

Reactant 3

HCID 241BenzeneHCID 6420Trichloroacetyl chlorideHCID 1676511-Phenylcyclopentylamine

Product 1

HCID 12879910HCID 12879910, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Into a 200 ml four-necked flask, there were charged benzene (100 ml), 1-phenylcyclopentylamine (8.1 g) and triethylamine (6.1 g), and trichloroacetyl chloride (9.1 g) was dropwise added thereto while stirring at room temperature. Stirring was continued for 3 hours. After completion of the reaction, the reaction mixture was washed with water to remove triethylamine hydrochloride. The benzene layer was dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The obtained residue was recrystallized from ethanol to give 12.4 g g of N-(1-phenylcyclopentyl)trichloroacetamide. M.P., 114°-115.5° C.

Workup

  1. additionwas dropwise added
  2. stirringStirring
  3. customAfter completion of the reaction
  4. washthe reaction mixture was washed with water
  5. customto remove triethylamine hydrochloride
  6. dry with materialThe benzene layer was dried over anhydrous sodium sulfate
  7. distillationthe solvent was distilled off under reduced pressure
  8. customThe obtained residue was recrystallized from ethanol

Sources & evidence

ORD record
ord-a198fd8986e64e40b045fc561cf2a319
Source dataset
uspto-grants-1981_05
Patent number
US04270002

Reaction notes

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