Triethylamine → HCID 15454940, compound

HRID 2287511Notes

Reaction equation

HRID 2287511 reaction equation
[CH2:1]([O:8][C:9]([N:11]1[C@H:15]([CH2:16]I)[C@@H:14]([CH2:18][O:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[C@H:13]([NH:27][C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[C@@H:12]1[C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CCN(CC)CC>CCO.CCOC(C)=O.[Pd]>[CH2:1]([O:8][C:9]([N:11]1[C@H:15]([CH3:16])[C@H:14]([CH2:18][O:19][CH2:20][C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[C@H:13]([NH:27][C:28]([O:30][C:31]([CH3:33])([CH3:34])[CH3:32])=[O:29])[C@@H:12]1[C:35]1[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 8471TriethylamineHCID 15454939HCID 15454939, compound

Product 1

HCID 15454940HCID 15454940, compoundYield 95.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 21584252Ethanol ethylacetateSolvent

Procedure

A mixture of (2S*,3S*,4S*,5S*)-1-benzyloxycarbonyl-4-benzyloxymethyl-3-[N-(t-butoxycarbonyl)amino]-5-iodomethyl-2-phenylpyrrolidine (9.85 g, 15.0 mml), Et3N (5.23 ml, d0.726, 37.5 mmol), and 10% Pd-C (1.83 g) in EtOH-AcOEt (2:1, 210 ml) was stirred under a slightly positive pressure of H2 (baloon) at room temperature for 5 hours, during which the white solids of Et3NH+I- precipitated. The catalysts and white precipitates were filtered off by the aid of a Celite pad, and washed with AcOEt followed by CH2Cl2 throughly. The combined filtrate and washings were concentrated in vacuo. The residue was diluted with PhMe-AcOEt (1:1, 200 ml), washed with sat. Na2SO3 aq. solution (×3), H2O (×2), and sat. NaCl aq. solution (×1), dried (MgSO4), and concentrated in vacuo to give the title compound (7.60 g, 95%) as slightly yellow solids. This was employed in the next step without further purification. A portion of it (0.15 g) was recrystallized from AcOEt-n-hexane to give an analytical sample of the title compound (0.11 g, 65%) as white fine needles (mp 143-144 C.): IRmax (nujol): 3380(s), 1710(s), 1688(s), 1520(s), 1500(w), 770(m), 738(s), 715(s), 698(s) cm-1 ; 1H-NMR δ: 7.50-7.17(m, 1H), 7.12-6.93(m,1H), 5.25(d, J=8.4 Hz, 1H), 5.04(br.s, 2H), 4.49(br.s, 2H), 4.26(ddd, J=11.3, 9.0, 9.0 Hz, 1H), 4.16-4.00(m, 1H), 3.95-3.77(m, 1H), 3.55(br.d, J=4.8 Hz, 2H), 1.97-1.80(m, 1H), 1.63(br.d, J=4.4 Hz, 3H), 1.40(br.s, 9H) ppm.

Workup

  1. customThe catalysts and white precipitates
  2. filtrationwere filtered off by the aid of a Celite pad
  3. washwashed with AcOEt
  4. concentrationThe combined filtrate and washings were concentrated in vacuo
  5. additionThe residue was diluted with PhMe-AcOEt (1:1, 200 ml)
  6. washwashed with sat. Na2SO3 aq. solution (×3), H2O (×2), and sat. NaCl aq. solution (×1)
  7. dry with materialdried (MgSO4)
  8. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-761cee67390b44a5894342782a4db7a1
Source dataset
uspto-grants-2000_07
Patent number
US06083943

Reaction notes

Loading…