反应详情

3-Hydroxy-6-methyl-pyridine-2-carbaldehyde (350 mg) was dissolved in tetrahydrofuran (13 ml) to prepare a solution which was brought to −78° C. Phenylmagnesium bromide (7.4 ml) was slowly added dropwise thereto, and the mixture was stirred at room temperature for one hr. Water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was then washed with saturated brine and was dried over anhydrous sodium sulfate. The solvent was removed by distillation under the reduced pressure, and the residue was purified by thin layer chromatography using chloroform-acetone to give 2-(hydroxyphenyl-methyl)-6-methyl-pyridin-3-ol (553 mg, yield 100%).

1. customto prepare a solution which
2. customwas brought to −78° C
3. extractionthe mixture was extracted with ethyl acetate
4. washThe ethyl acetate layer was then washed with saturated brine
5. dry with materialwas dried over anhydrous sodium sulfate
6. customThe solvent was removed by distillation under the reduced pressure
7. customthe residue was purified by thin layer chromatography