Acetic Anhydride → HCID 10797410, compound

HRID 2287565Notes

Reaction equation

HRID 2287565 reaction equation
[CH3:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([CH3:10])[C:3]=1[CH2:4][OH:5].[C:11](OC(=O)C)(=[O:13])[CH3:12]>CN(C)C1C=CN=CC=1>[C:11]([O:5][CH2:4][C:3]1[C:6]([CH3:10])=[CH:7][CH:8]=[CH:9][C:2]=1[CH3:1])(=[O:13])[CH3:12]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 186748(2,6-Dimethylphenyl)methanol

Product 1

HCID 10797410HCID 10797410, compound

Reagents, catalysts & solvents 1

HCID 142844-(Dimethylamino)pyridineCatalyst

Conditions

Temperature
70 °C

Procedure

To a mixture of 2,6-dimethylbenzyl alcohol (17.1 g) and acetic anhydride (14.2 ml) was added 4-dimethylaminopyridine (17 mg), and the mixture was stirred at 70° C. for 5 hours. After cooling, the mixture was concentrated in vacuo, and ethyl acetate was added to the residue. The solution was washed with water, dried over magnesium sulfate and evaporated in vacuo to give 2,6-dimethylbenzyl acetate (22.5 g) as colorless oil.

Workup

  1. temperatureAfter cooling
  2. concentrationthe mixture was concentrated in vacuo, and ethyl acetate
  3. additionwas added to the residue
  4. washThe solution was washed with water
  5. dry with materialdried over magnesium sulfate
  6. customevaporated in vacuo

Sources & evidence

ORD record
ord-6b413ced0f624f07bed78c784c7e2f69
Source dataset
uspto-grants-2000_07
Patent number
US06083961

Reaction notes

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