Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-methyl-1H-imidazole-4-sulfonyl chloride | HCID 2736887 | — |
| Reactant | HCID 53917738 | HCID 53917738 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 57184532 | HCID 57184532 | — |
Reaction Steps
Using procedure 9, (R)-7-(dipropylamino)-5,6,7,8-tetrahydro-2-naphthalenemethanamine 9 and triethylamine in dry tetrahydrofuran was cooled to 15° C., and 1-methylimidazole-4-sulfonyl chloride was added. After extraction, purification by flash chromatography (tetrahydrofuran/ethyl acetate) gave the title compound as an oil. [α]D =+46° (25° C., CH3OH, c=0.7458).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06084130 |
|---|
| Source dataset | uspto-grants-2000_07 |
|---|
| ORD ID | ord-0f32248b56cb4878986af5e666af5aff |
|---|
| Source note | uspto-grants-2000_07 |
|---|
