Propane, 1-bromo-3-fluoro- → HCID 18705898, compound

HRID 2287847Notes

Reaction equation

HRID 2287847 reaction equation
[CH2:1]([N:4]([CH2:18][CH2:19][CH3:20])[CH:5]1[CH2:13][C:12]2[C:7](=[CH:8][C:9]([OH:17])=[C:10]([C:14]([NH2:16])=[O:15])[CH:11]=2)[CH2:6]1)[CH2:2][CH3:3].Br[CH2:22][CH2:23][CH2:24][F:25]>>[CH2:18]([N:4]([CH2:1][CH2:2][CH3:3])[CH:5]1[CH2:13][C:12]2[C:7](=[CH:8][C:9]([O:17][CH2:22][CH2:23][CH2:24][F:25])=[C:10]([C:14]([NH2:16])=[O:15])[CH:11]=2)[CH2:6]1)[CH2:19][CH3:20]

Participants

3

Reactant 2

HCID 67699Propane, 1-bromo-3-fluoro-HCID 18705820HCID 18705820, compound

Product 1

HCID 18705898HCID 18705898, compound

Procedure

Using procedure 44, 2-(Dipropylamino)-2,3-dihydro-6-hydroxy-1H-indene-5-carboxamide (87, 0.19 g, 0.7 mmol) was treated with 1-bromo-3-fluoropropane (0.296 g, 2.1 mmol). Chromatographic purification yielded pure product 89 as a oil which was converted into the HCl salt and crystallized from EtOAc/MeOH to give a white solid (m.p. 219-220° C.).

Workup

  1. customChromatographic purification

Sources & evidence

ORD record
ord-59fed2d24b6a4aee94daadcddf9474ce
Source dataset
uspto-grants-2000_07
Patent number
US06084130

Reaction notes

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